Serum erythropoietin and granulocyte-macrophage-colony stimulating factor levels with megadose methylprednisolone treatment.

Abstract

Serum erythropoietin (EPO) and granulocyte-macrophage-colony stimulating factor (GM-CSF) levels were determined in 12 children with acute and seven with chronic idiopathic thrombocytopenic purpura (ITP) prior to and during megadose methylprednisolone (MDMP) treatment by using enzyme-linked immunosorbant assay (ELISA) kits. It was shown that elevation of EPO and GM-CSF levels was correlated with an increase in hemoglobin (Hb), packed cell volume (PCV), red blood cell (RBC), leukocyte (Leu), polymorphonuclear leukocyte (PMN) and monocyte (Mo) counts during MDMP treatment.

• Authors: T R Sayli, S Ozsoylu
• Journal: The Turkish journal of pediatrics (Turk J Pediatr) 1996 Oct-Dec Vol. 38 Issue 4 Pg. 491-5 ISSN: 0041-4301 [Print] Turkey
• PMID: 8993179 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Erythropoietin
• Granulocyte-Macrophage Colony-Stimulating Factor
• Methylprednisolone

Topics

• Anti-Inflammatory Agents (administration & dosage, therapeutic use)
• Erythropoietin (blood)
• Granulocyte-Macrophage Colony-Stimulating Factor (blood)
• Humans
• Methylprednisolone (administration & dosage, therapeutic use)
• Purpura, Thrombocytopenic, Idiopathic (blood, drug therapy)