Abstract |
The putative role of the dopaminergic system in sleep bruxism (SB) was studied in a double-blind clinical trial by using low doses of short-term L-dopa in combination with benserazide. We recorded 10 patients with SB in our sleep laboratory for 3 consecutive nights. The first night was for habituation to the laboratory environment. During the second and the third nights, the patients received two doses of either L-dopa or a placebo in a crossover fashion: the first dose 1 h before bedtime and the second, 4 h after the first one. The order of administration was reversed in half the patients. The efficacy of L-dopa was analyzed by using multilevel models. L-Dopa resulted in a significant decrease in the average number of bruxism episodes per hour of sleep, as well as in a significant reduction in the average value of the root-mean-square (RMS) electromyography (EMG) level per bruxism burst. This indicates that L-dopa exerts an attenuating effect on SB. In addition, L-dopa caused a reduction in the variance in RMS values, which suggests that L-dopa normalizes the EMG activity patterns associated with SB.
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Authors | F Lobbezoo, G J Lavigne, R Tanguay, J Y Montplaisir |
Journal | Movement disorders : official journal of the Movement Disorder Society
(Mov Disord)
Vol. 12
Issue 1
Pg. 73-8
(Jan 1997)
ISSN: 0885-3185 [Print] United States |
PMID | 8990057
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dopamine Agents
- Drug Combinations
- Levodopa
- Benserazide
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Topics |
- Adult
- Benserazide
(administration & dosage)
- Bruxism
(drug therapy)
- Cross-Over Studies
- Dopamine Agents
(administration & dosage)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Administration Schedule
- Drug Combinations
- Electromyography
(drug effects)
- Female
- Humans
- Levodopa
(administration & dosage)
- Male
- Polysomnography
- Sleep Wake Disorders
(drug therapy)
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