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Identification of children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections by a marker associated with rheumatic fever.

AbstractOBJECTIVE:
The authors' goal was to determine whether a trait marker of rheumatic fever susceptibility (labeled D8/17) could identify children with pediatric autoimmune neuropsychiatric disorders (obsessive-compulsive disorder and tic disorders) associated with streptococcal infections (PANDAS).
METHOD:
Blood samples obtained from 27 children with PANDAS, nine children with Sydenham's chorea, and 24 healthy children were evaluated for D8/17 reactivity. Individuals were defined as D8/17 positive if they had 12% or more D8/17+ cells.
RESULTS:
The frequency of D8/17-positive individuals was significantly higher in both patient groups than it was among the healthy volunteers: 85% of the children with PANDAS and 89% of the children with Sydenham's chorea, compared with 17% of the healthy children, were D8/17 positive. Further, the mean number of D8/17+ cells was similar in the two patient groups and was significantly higher in these groups than in the group of healthy children.
CONCLUSIONS:
These results suggest that there may be a subgroup of D8/17-positive children who present with clinical symptoms of obsessive-compulsive disorder and Tourette's syndrome, rather than Sydenham's chorea, but who have similar poststreptococcal autoimmunity.
AuthorsS E Swedo, H L Leonard, B B Mittleman, A J Allen, J L Rapoport, S P Dow, M E Kanter, F Chapman, J Zabriskie
JournalThe American journal of psychiatry (Am J Psychiatry) Vol. 154 Issue 1 Pg. 110-2 (Jan 1997) ISSN: 0002-953X [Print] United States
PMID8988969 (Publication Type: Journal Article)
Chemical References
  • Antibodies, Monoclonal
  • Biomarkers
  • HLA-DR Antigens
Topics
  • Adolescent
  • Antibodies, Monoclonal (immunology)
  • Autoimmune Diseases (diagnosis, immunology)
  • Biomarkers
  • Child
  • Child, Preschool
  • Chorea (immunology)
  • Female
  • Genetic Predisposition to Disease
  • HLA-DR Antigens (immunology)
  • Humans
  • Lymphocyte Subsets (immunology)
  • Male
  • Obsessive-Compulsive Disorder (diagnosis)
  • Rheumatic Fever (genetics, immunology)
  • Streptococcal Infections (immunology)

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