Abstract | OBJECTIVE: The authors' goal was to determine whether a trait marker of rheumatic fever susceptibility (labeled D8/17) could identify children with pediatric autoimmune neuropsychiatric disorders (obsessive-compulsive disorder and tic disorders) associated with streptococcal infections (PANDAS). METHOD: Blood samples obtained from 27 children with PANDAS, nine children with Sydenham's chorea, and 24 healthy children were evaluated for D8/17 reactivity. Individuals were defined as D8/17 positive if they had 12% or more D8/17+ cells. RESULTS: The frequency of D8/17-positive individuals was significantly higher in both patient groups than it was among the healthy volunteers: 85% of the children with PANDAS and 89% of the children with Sydenham's chorea, compared with 17% of the healthy children, were D8/17 positive. Further, the mean number of D8/17+ cells was similar in the two patient groups and was significantly higher in these groups than in the group of healthy children. CONCLUSIONS: These results suggest that there may be a subgroup of D8/17-positive children who present with clinical symptoms of obsessive-compulsive disorder and Tourette's syndrome, rather than Sydenham's chorea, but who have similar poststreptococcal autoimmunity.
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Authors | S E Swedo, H L Leonard, B B Mittleman, A J Allen, J L Rapoport, S P Dow, M E Kanter, F Chapman, J Zabriskie |
Journal | The American journal of psychiatry
(Am J Psychiatry)
Vol. 154
Issue 1
Pg. 110-2
(Jan 1997)
ISSN: 0002-953X [Print] United States |
PMID | 8988969
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Biomarkers
- HLA-DR Antigens
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Topics |
- Adolescent
- Antibodies, Monoclonal
(immunology)
- Autoimmune Diseases
(diagnosis, immunology)
- Biomarkers
- Child
- Child, Preschool
- Chorea
(immunology)
- Female
- Genetic Predisposition to Disease
- HLA-DR Antigens
(immunology)
- Humans
- Lymphocyte Subsets
(immunology)
- Male
- Obsessive-Compulsive Disorder
(diagnosis)
- Rheumatic Fever
(genetics, immunology)
- Streptococcal Infections
(immunology)
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