Hepatic angiosarcoma in a child: successful therapy with surgery and adjuvant chemotherapy.

Abstract

We report a 3-year and 11-month-old Caucasian female, who initially presented with an unresectable hepatic angiosarcoma. After three courses of chemotherapy with adriamycin/cisplatin, the tumor decreased in size considerably, allowing complete surgical resection. She also received postoperative chemotherapy with alternating cycles of ifosfamide/etoposide, cisplatinum/adriamycin, and vincristine/actinomycin D/cyclophosphamide for 18 months. She remains disease-free for greater than 44 months from the initial diagnosis. Our experience suggests that total excision of the tumor, together with an aggressive chemotherapy regimen, can improve the disease-free survival for children with this highly malignant vascular tumor of the liver.

• Authors: S W Gunawardena, L M Trautwein, M J Finegold, A K Ogden
• Journal: Medical and pediatric oncology (Med Pediatr Oncol) Vol. 28 Issue 2 Pg. 139-43 (Feb 1997) ISSN: 0098-1532 [Print] United States
• PMID: 8986151 (Publication Type: Case Reports, Journal Article)

Chemical References

• Dactinomycin
• Vincristine
• Etoposide
• Doxorubicin
• Cyclophosphamide
• Cisplatin
• Ifosfamide

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Chemotherapy, Adjuvant
• Child, Preschool
• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Cyclophosphamide (administration & dosage)
• Dactinomycin (administration & dosage)
• Doxorubicin (administration & dosage)
• Drug Administration Schedule
• Etoposide (administration & dosage)
• Female
• Hemangiosarcoma (drug therapy, surgery)
• Humans
• Ifosfamide (administration & dosage)
• Liver Neoplasms (drug therapy, surgery)
• Vincristine (administration & dosage)