Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS.

Abstract

Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)-reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mice are characterized by utilization of a FK506-insensitive pathway for clonal expansion of superantigen-reactive T cells.

• Authors: Y Yoshikai, H Kidokoro, K Kimura, Y Aoki, M Makino, K Hiromatsu
• Journal: Journal of virology (J Virol) Vol. 71 Issue 1 Pg. 746-9 (Jan 1997) ISSN: 0022-538X [Print] United States
• PMID: 8985410 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Calmodulin-Binding Proteins
• Enterotoxins
• Immunosuppressive Agents
• Interleukin-2
• Superantigens
• enterotoxin A, Staphylococcal
• Cyclosporine
• Calcineurin
• Phosphoprotein Phosphatases
• Tacrolimus

Topics

• Animals
• Calcineurin
• Calmodulin-Binding Proteins (antagonists & inhibitors)
• Cell Line
• Cyclosporine (pharmacology)
• Enterotoxins (pharmacology)
• Female
• Immunosuppressive Agents (pharmacology)
• Interleukin-2 (biosynthesis)
• Leukemia Virus, Murine (immunology)
• Mice
• Mice, Inbred C57BL
• Murine Acquired Immunodeficiency Syndrome (immunology)
• Phosphoprotein Phosphatases (antagonists & inhibitors)
• Superantigens (pharmacology)
• T-Lymphocytes (cytology, drug effects, immunology)
• Tacrolimus (pharmacology)