Studies on the pathogenesis of cancer hypercalcemia.

Abstract

The pathogenesis of hypercalcemia in cancer continues to challenge the clinical investigator. Some aspects of this subject have been reviewed, notably with respect to the possible roles of prostaglandins and osteoclast activating factor, with particular reference to breast cancer. There is considerable evidence that the former humoral factor is operative and beginning evidence that the latter may be also. The hope in this continued work is that with better understanding of the mechanisms of hypercalcemia and bone loclization of tumors we will be in a far better position to control and interdict this localization.

• Authors: W P Laird Myers, R Bockman
• Journal: Transactions of the American Clinical and Climatological Association (Trans Am Clin Climatol Assoc) Vol. 88 Pg. 177-90 ( 1977) ISSN: 0065-7778 [Print] United States
• PMID: 898535 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Parathyroid Hormone

Topics

• Adult
• Aged
• Breast Neoplasms (complications)
• Female
• Humans
• Hypercalcemia (complications, etiology, physiopathology)
• Male
• Middle Aged
• Neoplasms (complications)
• Neoplasms, Experimental (complications)
• Osteoclasts (pathology, physiopathology)
• Parathyroid Hormone (biosynthesis)
• Penile Neoplasms (complications)
• Pleural Neoplasms (complications)