Caparratriene, an active sesquiterpene hydrocarbon from Ocotea caparrapi.

Abstract

Caparratriene (1), a new sesquiterpene hydrocarbon with significant growth inhibitory activity (IC50 = 3.0 +/- 0.5 x 10(-6) M) against CEM leukemia cells, was isolated from the oil of Ocotea caparrapi (Nates) Dugand. The structure of 1, determined by spectroscopic techniques, corresponded to (E,E)-3,7,11-trimethyl-2,4,10-dodecatriene (C15H26).

• Authors: E Palomino, C Maldonado, M B Kempff, M B Ksebati
• Journal: Journal of natural products (J Nat Prod) Vol. 59 Issue 1 Pg. 77-9 (Jan 1996) ISSN: 0163-3864 [Print] United States
• PMID: 8984157 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Sesquiterpenes
• caparratriene

Topics

• Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology)
• Colombia
• Gas Chromatography-Mass Spectrometry
• Humans
• Leukemia, Experimental (drug therapy)
• Magnetic Resonance Spectroscopy
• Plants, Medicinal (chemistry)
• Sesquiterpenes (isolation & purification, pharmacology)
• Spectrophotometry, Infrared
• Spectrophotometry, Ultraviolet
• Tumor Cells, Cultured