Role of glucose-6-phosphate in cerebral dysfunction following hypoxia and hypotension.

Abstract

Rats were "stressed" by a 30-minute period of breathing 7.5% oxygen combined with hemorrhagic hypotension (x arterial pressure = 25 mm Hg), and then "resuscitated" by restoring the inspired oxygen concentration to 30% and reinfusing the blood previously removed to produce hypotension. We have previously noted in initial return of brain adenosine-triphosphate to normal after this "stress" followed by a progressive decline during the post-resuscitation period. In this study, substrate deficiency was investigated as a possible etiology for the decreased adenosine-triphosphate. Glucose and glucose-6-phosphate concentrations in the brain were measured before "stress" and after resuscitation and were found not to change, indicating no deficiency of substrate.

• Authors: H J Proctor, J J Wood
• Journal: Surgical neurology (Surg Neurol) Vol. 8 Issue 3 Pg. 225-6 (Sep 1977) ISSN: 0090-3019 [Print] United States
• PMID: 897997 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Glucosephosphates

Topics

• Animals
• Brain (metabolism)
• Disease Models, Animal
• Glucosephosphates (metabolism)
• Hypotension (metabolism)
• Hypoxia (metabolism)
• Male
• Rats