Abstract |
Effect of UL-409, a multiconstituent herbal preparation was evaluated on different models of gastric ulcers in rats. In doses 25, 50 and 100 mg/kg. p.o. it significantly reduced the gastric secretory volume and ulcer index in pylorus ligated rats, and showed significant mucoprotective effect at 100 mg/kg dose on both acute and chronic treatment. UL-409(50 and 100 mg/kg doses) prevented immobilization induced gastric ulceration and showed significant mucosal protection. In forced swimming induced ulcers, UL-4093(50 and 100 mg/kg) completely abolished the ulcerogenesis and strengthened the mucosal barrier. It also protected the indomethacin-induced gastric ulcers and significantly increased the mucosal content. Cimetidine (10 mg/kg) and diazepam (20 mg/kg) were used for comparison. The results indicate that UL-409 has anti-ulcerogenic effects due to its mucoprotective effect. The preparation can be used alone or in combination with other ulcer healing agents.
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Authors | S K Kulkarni, R K Goel |
Journal | Indian journal of experimental biology
(Indian J Exp Biol)
Vol. 34
Issue 7
Pg. 683-8
(Jul 1996)
ISSN: 0019-5189 [Print] India |
PMID | 8979506
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Anti-Ulcer Agents
- Plant Extracts
- UL 409
- Cimetidine
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Topics |
- Animals
- Anti-Ulcer Agents
(therapeutic use)
- Cimetidine
(therapeutic use)
- Female
- Male
- Medicine, Ayurvedic
- Plant Extracts
(therapeutic use)
- Rats
- Rats, Inbred Strains
- Stomach Ulcer
(drug therapy, etiology)
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