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Gastric antiulcer activity of UL-409 in rats.

Abstract
Effect of UL-409, a multiconstituent herbal preparation was evaluated on different models of gastric ulcers in rats. In doses 25, 50 and 100 mg/kg. p.o. it significantly reduced the gastric secretory volume and ulcer index in pylorus ligated rats, and showed significant mucoprotective effect at 100 mg/kg dose on both acute and chronic treatment. UL-409(50 and 100 mg/kg doses) prevented immobilization induced gastric ulceration and showed significant mucosal protection. In forced swimming induced ulcers, UL-4093(50 and 100 mg/kg) completely abolished the ulcerogenesis and strengthened the mucosal barrier. It also protected the indomethacin-induced gastric ulcers and significantly increased the mucosal content. Cimetidine (10 mg/kg) and diazepam (20 mg/kg) were used for comparison. The results indicate that UL-409 has anti-ulcerogenic effects due to its mucoprotective effect. The preparation can be used alone or in combination with other ulcer healing agents.
AuthorsS K Kulkarni, R K Goel
JournalIndian journal of experimental biology (Indian J Exp Biol) Vol. 34 Issue 7 Pg. 683-8 (Jul 1996) ISSN: 0019-5189 [Print] India
PMID8979506 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Anti-Ulcer Agents
  • Plant Extracts
  • UL 409
  • Cimetidine
Topics
  • Animals
  • Anti-Ulcer Agents (therapeutic use)
  • Cimetidine (therapeutic use)
  • Female
  • Male
  • Medicine, Ayurvedic
  • Plant Extracts (therapeutic use)
  • Rats
  • Rats, Inbred Strains
  • Stomach Ulcer (drug therapy, etiology)

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