[Effect of FUT-187, oral serine protease inhibitor, on inflammation in the gastric remnant].
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| Abstract |
Excessive enterogastric reflux following partial gastrectomy is believed to be responsible for the cause of inflammation in the gastric remnant. We examined the effect of FUT-187, a synthetic serine protease inhibitor, on symptoms and endoscopic findings in 33 patients who were diagnosed endoscopically as postgastrectomy gastritis. Patients took 50 mg FUT-187 orally after each meal and at bedtime for 8 weeks. Before treatment, 30 patients (91%) suffered from several symptoms including regurgitation and/or bitter taste in the mouth (49%), epigastric pain (42%) and nausea (36%). From endoscopic observation, erythema was detected in 32 patients, edema in 23 patients and erosion and/or ulcer in 9 patients. After treatment the global improvement rating for subjective symptoms was 76.7% (23/30) and the improvement of endoscopic findings was 63.6% (21/33). Diarrhea was observed in one patient but could be easily controlled by discontinuation of the drug. Our results suggest that FUT-187 can be a useful drug for the treatment of postgastrectomy gastritis with its efficacy and safety.
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| Authors | H Shiozaki, M Inoue, S Tamura, T Iwanaga, M Imaoka, H Furukawa, M Hiratsuka, N Kikkawa, K Kobayashi, J Okamura, N Takada, Y Ogawa, T Yamada, M Takami, T Takada, H Okuda, T Yano, T Satomi, T Kawasaki, S Oshima, K Yamasaki, H Imamoto, S Noguchi, N Fujimoto, T Mori |
| Journal | Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 23 Issue 14 Pg. 1971-9 (Dec 1996) ISSN: 0385-0684 [Print] Japan |
| PMID | 8978806 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study) |
| Chemical References |
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