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Defective growth hormone secretion in children with pycnodysostosis and improved linear growth after growth hormone treatment.

Abstract
Short stature is a characteristic feature of pycnodysostosis. We report defective growth hormone secretion in response to provocation and low insulin-like growth factor-I (IGF-I) concentration in five out of six patients with pycnodysostosis. Physiological replacement with growth hormone increased IGF-I concentration and improved linear growth in these children.
AuthorsA T Soliman, A Rajab, I AlSalmi, A Darwish, M Asfour
JournalArchives of disease in childhood (Arch Dis Child) Vol. 75 Issue 3 Pg. 242-4 (Sep 1996) ISSN: 1468-2044 [Electronic] England
PMID8976667 (Publication Type: Journal Article)
Chemical References
  • Insulin-Like Growth Factor I
  • Growth Hormone
Topics
  • Adult
  • Bone Diseases, Developmental (metabolism, physiopathology, therapy)
  • Child, Preschool
  • Female
  • Growth (physiology)
  • Growth Disorders (metabolism, physiopathology, therapy)
  • Growth Hormone (blood, metabolism, therapeutic use)
  • Humans
  • Infant
  • Infant, Newborn
  • Insulin-Like Growth Factor I (metabolism)
  • Male

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