RTVP-1, a novel human gene with sequence similarity to genes of diverse species, is expressed in tumor cell lines of glial but not neuronal origin.

Abstract

A novel gene, RTVP-1, which shows significant sequence identity to the mammalian testis-specific proteins, a family of plant pathogenesis-related proteins and the vespid venom allergen, antigen-5, has been isolated from a cDNA library of the human glioblastoma brain tumor cell line, U-251 MG. The highest degree of sequence identity was with the human testis-specific protein, TPX1 (38.7% over 119 amino acids). Northern hybridization analysis revealed that in fetal tissue RTVP-1 RNA was detected only in the kidney, but its expression was ubiquitous in adult tissues including brain. Multiple mRNAs encoded by RTVP-1 were highly expressed in a panel of cell lines from nervous system tumors arising from glia, although expression was low or absent in nonglial-derived nervous system tumor cell lines.

• Authors: T Rich, P Chen, F Furman, N Huynh, M A Israel
• Journal: Gene (Gene) Vol. 180 Issue 1-2 Pg. 125-30 (Nov 21 1996) ISSN: 0378-1119 [Print] Netherlands
• PMID: 8973356 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• GLIPR1 protein, human
• Glycoproteins
• Membrane Proteins
• Neoplasm Proteins
• Nerve Tissue Proteins
• RNA, Messenger
• Recombinant Proteins
• DNA

Topics

• Amino Acid Sequence
• Base Sequence
• DNA
• Gene Expression
• Glycoproteins (genetics)
• Membrane Proteins
• Molecular Sequence Data
• Neoplasm Proteins (genetics)
• Nerve Tissue Proteins
• Neuroglia (metabolism)
• Neurons (metabolism)
• RNA, Messenger (metabolism)
• Recombinant Proteins (genetics)
• Sequence Homology, Amino Acid
• Tumor Cells, Cultured