Abstract |
In vitro and in vivo studies were done to examine the effects of methylprednisolone on the adverse reactions induced by contrast media. At very high concentrations, the steroid potentiated the complement-activating effect produced in vitro by iodipamide, but inhibited the immune and nonimmune mechanisms of hemolysis. Rabbits pretreated for 3 days with intramuscular methylprednisolone (at high or low dosages) were significantly protected against an LD47 challenging dose of iodipamide. Those treated once with a low intravenous dose immediately prior to iodipamide challenge were protected to a lesser degree. Rabbits treated once with a very high intravenous dose of steroid evidenced no protection. A hyper-responsive dog was consistently protected against adverse reactions to injected sodium iothalamate by a 3-day steroid pretreatment.
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Authors | E C Lasser, J Lang, M Sovak, W Kolb, S Lyon, A E Hamlin |
Journal | Radiology
(Radiology)
Vol. 125
Issue 1
Pg. 1-9
(Oct 1977)
ISSN: 0033-8419 [Print] United States |
PMID | 897151
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Contrast Media
- Iothalamic Acid
- Complement System Proteins
- Prednisolone
- Iodipamide
- Methylprednisolone
- Iothalamate Meglumine
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Topics |
- Animals
- Complement System Proteins
- Contrast Media
(adverse effects)
- Dogs
- Drug Hypersensitivity
(etiology, prevention & control)
- Hemolysis
(drug effects)
- Humans
- Iodipamide
(administration & dosage, adverse effects)
- Iothalamate Meglumine
(adverse effects)
- Iothalamic Acid
(adverse effects)
- Methylprednisolone
(therapeutic use)
- Prednisolone
(therapeutic use)
- Rabbits
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