Abstract | OBJECTIVE: To determine the efficacy of a single oral dose of 150,000 IU of vitamin D2 at the beginning of autumn for preventing winter vitamin D deficiency in children in Ushuaia (55 degrees S). DESIGN: The study was prospective. SUBJECTS: 79 children clinically healthy with 8.6 +/- 1.4 y of age (X +/- s.d.). INTERVENTIONS: Fasting serum venous samples and 2 h urine samples were obtained immediately before and 6 w and 5 mon after the vitamin D dose. Parents informed consent was obtained previous to the study. In a subgroup of 30 children serum levels of calcium (sCa), phosphorus (sP), total alkaline phosphatase (TAP), 25 hydroxyvitamin D (25 OHD), parathyroid hormone (PTH) and the urine calcium/ creatinine ratio in a 2 h urine sample (UCa/UCreat) were measured. In the whole group sCa and the ratio uCa/ucreat were measured. RESULTS: After 150,000 IU of vitamin D2 administration, serum 25 OHD levels at the end of winter (17.0 +/- 9.4 ng/ml) were similar to those at the beginning of autumn (18.7 +/- 10.7 ng/ml), but significantly higher from those obtained in a previous study without vitamin D (9.8 +/- 3.8 ng/ml, P < 0.001). PTH levels were higher at the end of winter (P < 0.02), but this augmentation was lower than the increment observed without vitamin D. Plasma calcium levels and the urine calcium/ creatinine ratio were lower at 5 months after vitamin D2 dose (P < 0.02 and P < 0.05 respectively). In the total group the serum calcium was lower after the fifth month (P < 0.05). The Uca/Ucreat ratio was lower at 6 w and 5 mon (P < 0.05 and P < 0.001). CONCLUSION: A single dose of 150,000 IU of vitamin D maintained appropriate levels of 25 OHD without inducing hypercalcemia nor hypercalciuria, but a winter increment of PTH (smaller than in the group without vitamin D) was not inhibited.
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Authors | B Oliveri, H Cassinelli, C Mautalen, M Ayala |
Journal | European journal of clinical nutrition
(Eur J Clin Nutr)
Vol. 50
Issue 12
Pg. 807-10
(Dec 1996)
ISSN: 0954-3007 [Print] England |
PMID | 8968701
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Ergocalciferols
- Parathyroid Hormone
- Phosphorus
- Creatinine
- Alkaline Phosphatase
- Calcifediol
- Calcium
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Topics |
- Alkaline Phosphatase
(blood)
- Argentina
- Calcifediol
(blood)
- Calcium
(blood, urine)
- Child
- Child, Preschool
- Creatinine
(urine)
- Ergocalciferols
(administration & dosage, therapeutic use)
- Humans
- Parathyroid Hormone
(blood)
- Phosphorus
(blood)
- Prospective Studies
- Seasons
- Vitamin D Deficiency
(prevention & control)
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