Erythrocyte alkaline phosphatase in patients with myotonic muscle disorders.

Abstract

The allosteric behaviour of the p-nitrophenyl-phosphatase (E.C.3.1.3.1.) from membrane erythrocytes was investigated in the following multisystemic diseases: myotonic dystrophy, limb-girdle muscular dystrophy, Charcot-Marie-Tooth and juvenile spinal muscular atrophy; in myotonia congenita, which is not a multisystemic disease, and in healthy controls. The Hill coefficient in F inhibition in controls was different from that in multisystemic diseases patients but not from that in myotonia congenita patients. Changes in the cooperative type kinetics would suggest that the interaction membrane-enzyme in controls and in patients with neuromuscular disorders is only different for multisystemic diseases.

• Authors: A L Goldemberg, E A Madrid, A M García, M Roubicek, R Esteban Trucco
• Journal: Investigacion clinica (Invest Clin) Vol. 37 Issue 4 Pg. 247-53 (Dec 1996) ISSN: 0535-5133 [Print] Venezuela
• PMID: 8968130 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkaline Phosphatase

Topics

• Alkaline Phosphatase (analysis)
• Erythrocyte Membrane (enzymology)
• Humans
• Muscular Dystrophies (blood, enzymology)
• Neuromuscular Diseases (blood, enzymology)