[Experimental study of possible treatment of Marburg hemorrhagic fever with desferal, ribavirin, and homologous interferon].

Abstract

The paper presents data on the effects of the drugs desferal, ribavirin and homologous (guinea pig) interferon on the course of experimental Marburg fever. Neither ribavirin nor interferon were effective. A moderate response to desferal was noted. It is suggested that tumor necrosis factor may contribute to development of Marburg hemorrhagic fever.

• Authors: G M Ignat'ev, M A Strel'tsova, A P Agafonov, E A Kashentseva, N S Prozorovskiĭ
• Journal: Voprosy virusologii (Vopr Virusol) 1996 Sep-Oct Vol. 41 Issue 5 Pg. 206-9 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Eksperimental'noe izuchenie vozmozhnosti lecheniia gemorragicheskoĭ likhoradki Marburg desferalom, ribavirinom i gomologichnym interferonom.
• PMID: 8967064 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antibodies, Viral
• Antiviral Agents
• Tumor Necrosis Factor-alpha
• Ribavirin
• Interferons
• Deferoxamine

Topics

• Animals
• Antibodies, Viral (blood)
• Antiviral Agents (therapeutic use)
• Deferoxamine (therapeutic use)
• Guinea Pigs
• Interferons (therapeutic use)
• Marburg Virus Disease (blood, drug therapy, virology)
• Marburgvirus (immunology)
• Ribavirin (therapeutic use)
• Tumor Necrosis Factor-alpha (analysis)
• Viremia