[Drug therapy of condylomata acuminata].

Abstract

This study seeks to evaluate two candidate regimens (5-fluorouracil and interferon) as adjuvants to optimally performed laser surgery in the treatment of condylomata acuminata. Skillful laser ablation can remove any volume of human papillomavirus-associated vulvar disease but cannot prevent reactivation of the surrounding latent viral reservoir during postoperative healing. Conversely, interferon and 5-fluorouracil are relatively ineffective as primary therapies. This study involves 118 evaluable patients: 32 in the laser-CO2 group, 34 in the 5-fluorouracil group and 52 in the interferon group. At assessment of final outcome, it was found that 43 of 52 (82%) assessable patients in the adjuvant interferon arm were controlled by a single laser ablation as compared with only 17 of 34 (50%) in the 5-fluorouracil group and 13 of 32 (40%) in the laser alone group. There was no statistical difference in outcome within the 5-fluorouracil and laser only arms. Conversely, a relatively low dose of recombinant interferon, used in combination with effective surgical deleulking, can markedly reduce the risk of postoperative recurrence.

• Authors: R Zarcone, E Carfora, P Bellini, G Vicinanza
• Journal: Minerva ginecologica (Minerva Ginecol) 1996 Jul-Aug Vol. 48 Issue 7-8 Pg. 299-302 ISSN: 0026-4784 [Print] Italy
• Vernacular Title: Trattamento farmacologico dei condilomi acuminati.
• PMID: 8966003 (Publication Type: Clinical Trial, Clinical Trial, Phase II, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Interferons
• Fluorouracil

Topics

• Adult
• Condylomata Acuminata (drug therapy, surgery, virology)
• Female
• Fluorouracil (therapeutic use)
• Humans
• Interferons (therapeutic use)
• Laser Therapy
• Papillomaviridae (isolation & purification)