Effect of nipradilol, a beta-adrenergic blocker with vasodilating activity, on oxotremorine-induced tremor in mice.

Abstract

The effect of nipradilol, a nonselective beta-adrenergic receptor blocker with nitroglycerin-like vasodilating activity, on oxotremorine-induced tremor was studied in mice. General tremor in mice was elicited by 0.5 mg/kg oxotremorine. The tremor was quantified using a capacitance transducer, then analyzed by a signal processor. The strength of the tremor was expressed in "points". The point values of the tremor (mean +/- SE) in control mice for 5 mg/kg (+/-)-propranolol, 2.5 mg/kg arotinolol, 0.5 mg/kg nipradilol, 1.0 mg/kg nipradilol and 2.5 mg/kg nipradilol were 87 +/- 16, 42 +/- 6, 38 +/- 6, 99 +/- 28, 28 +/- 6 and 31 +/- 7, respectively. The strength of the tremor was reduced by all beta-blockers. Although 1.0 mg/kg nipradilol significantly reduced the tremor, further inhibition of the tremor was not obtained with dosages up to 2.5 mg/kg of the drug. In conclusion, nipradilol was effective for suppressing oxotremorine-induced tremor, as were other beta-blockers.

• Authors: S Iwata, M Nomoto, T Fukuda
• Journal: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology (Nihon Shinkei Seishin Yakurigaku Zasshi) Vol. 16 Issue 5 Pg. 171-4 (Oct 1996) ISSN: 1340-2544 [Print] Japan
• PMID: 8962435 (Publication Type: Journal Article)

Chemical References

• Adrenergic beta-Agonists
• Propanolamines
• Vasodilator Agents
• Oxotremorine
• nipradilol

Topics

• Adrenergic beta-Agonists (pharmacology)
• Animals
• Male
• Mice
• Oxotremorine
• Propanolamines (pharmacology)
• Tremor (chemically induced, physiopathology, prevention & control)
• Vasodilator Agents (pharmacology)