| Abstract | Haemophilus influenzae type b (Hib) capsular polysaccharide (PS) conjugated to tetanus toxoid (PRP-T) was given at 4 and 6 months of age and anti-Hib PS antibody response to the first and second dose of PRP-T was compared in groups that received diphtheria-tetanus-pertussis (DTP) vaccine either simultaneously with PRP-T (34 infants) or separately at 3, 4 and 5 months of age (49 infants). The geometric mean anti-Hib PS antibody concentration after the first dose of PRP-T given at 4 months of age was eightfold higher if the infants primed with DTP at 3 months of age than if the first dose of DTP was given together with the first dose of PRP-T (0.81 microgram ml-1 vs 0.11 microgram ml-1). The positive influence of DTP priming was seen also after the second dose of PRP-T given at 6 months of age (7.55 micrograms ml-1 vs 3.45 micrograms ml-1). |
| Authors | S Kurikka
(Affiliation: National Public Health Institute, Helsinki, Finland.)
|
| Journal | Vaccine
(Vaccine)
Vol. 14
Issue 13
Pg. 1239-42
(Sep 1996)
ISSN: 0264-410X ENGLAND |
| PMID | 8961512
(Publication Type: Journal Article)
|
| Chemical References |
- Antibodies, Bacterial
- Bacterial Capsules
- Diphtheria-Tetanus-Pertussis Vaccine
- Haemophilus Vaccines
- Haemophilus influenza type b polysaccharide vaccine-tetanus toxin conjugate
- Haemophilus influenzae type b polysaccharide vaccine
- Polysaccharides, Bacterial
- Tetanus Antitoxin
- Tetanus Toxoid
- Vaccines, Conjugate
|
| Topics |
- Antibodies, Bacterial
(blood)
- Bacterial Capsules
- Diphtheria-Tetanus-Pertussis Vaccine
(immunology)
- Haemophilus Vaccines
(immunology)
- Humans
- Infant
- Polysaccharides, Bacterial
(immunology)
- Tetanus Antitoxin
(blood)
- Tetanus Toxoid
(immunology)
- Vaccines, Conjugate
(immunology)
|
