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Idiopathic arterial calcification of infancy: effectiveness of prostaglandin infusion for treatment of secondary hypertension refractory to conventional therapy: case report.

Abstract
A premature baby had severe hypertension associated with idiopathic arterial calcification of infancy. Despite the fact that there was laboratory evidence of renin-mediated hypertension, the disease was refractory to specific renin antagonist and failed to respond to conventional medical treatment. Prostaglandin E1 (PGE1) infusion (dosage range 0.017-0.068 microgram/kg/min) promptly controlled hypertension on two occasions. The drug was given for a total of 65 days and then stopped after the appearance of severe thrombocytopenia; other side effects included sporadic hyperthermia and irritability. Blood pressure was then stabilized satisfactory by a multiple-antihypertensive regimen. In the light of these findings, we believe that PGE1 infusion is a possible therapeutic alternative for babies with idiopathic arterial calcification complicated by severe hypertension refractory to conventional treatment.
AuthorsG Ciana, F Colonna, V Forleo, F Brizzi, A Benettoni, U de Vonderweid
JournalPediatric cardiology (Pediatr Cardiol) 1997 Jan-Feb Vol. 18 Issue 1 Pg. 67-71 ISSN: 0172-0643 [Print] United States
PMID8960499 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Prostaglandins E
Topics
  • Calcinosis (complications)
  • Echocardiography
  • Female
  • Humans
  • Hypertension (drug therapy, etiology)
  • Infant, Newborn
  • Infant, Premature
  • Prostaglandins E (adverse effects, therapeutic use)

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