Abstract |
A premature baby had severe hypertension associated with idiopathic arterial calcification of infancy. Despite the fact that there was laboratory evidence of renin-mediated hypertension, the disease was refractory to specific renin antagonist and failed to respond to conventional medical treatment. Prostaglandin E1 ( PGE1) infusion (dosage range 0.017-0.068 microgram/kg/min) promptly controlled hypertension on two occasions. The drug was given for a total of 65 days and then stopped after the appearance of severe thrombocytopenia; other side effects included sporadic hyperthermia and irritability. Blood pressure was then stabilized satisfactory by a multiple- antihypertensive regimen. In the light of these findings, we believe that PGE1 infusion is a possible therapeutic alternative for babies with idiopathic arterial calcification complicated by severe hypertension refractory to conventional treatment.
|
Authors | G Ciana, F Colonna, V Forleo, F Brizzi, A Benettoni, U de Vonderweid |
Journal | Pediatric cardiology
(Pediatr Cardiol)
1997 Jan-Feb
Vol. 18
Issue 1
Pg. 67-71
ISSN: 0172-0643 [Print] United States |
PMID | 8960499
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
|
Topics |
- Calcinosis
(complications)
- Echocardiography
- Female
- Humans
- Hypertension
(drug therapy, etiology)
- Infant, Newborn
- Infant, Premature
- Prostaglandins E
(adverse effects, therapeutic use)
|