Abstract |
Tallimustine binds to the minor groove of DNA where it alkylates the N3 position of adenine and may interfere with gene transcription. We conducted a phase II trial of Tallimustine given at a dose of 750 micrograms/m2 intravenously every 4 weeks in patients with small cell lung cancer progressing or relapsing following cisplatin or carboplatin-based chemotherapy. We treated 14 eligible patients with a performance status 0, 1 or 2, bi-dimensionally measurable disease and adequate end-organ function. The main toxicity was neutropenia with a median granulocyte count of 0.1 x 10(9) per liter (range 0-3.9) and four patients (27%) developing febrile neutropenia. In addition, most patients (93%) experienced lethargy. No objective responses were seen. A mixed response was seen in one patient and three others had stable disease for a median of 3.7 months. We conclude that Tallimustine is an ineffective agent in previously treated small cell lung cancer.
|
Authors | J Viallet, D Stewart, F Shepherd, J Ayoub, Y Cormier, N DiPietro, W Steward |
Journal | Lung cancer (Amsterdam, Netherlands)
(Lung Cancer)
Vol. 15
Issue 3
Pg. 367-73
(Nov 1996)
ISSN: 0169-5002 [Print] Ireland |
PMID | 8959681
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antineoplastic Agents
- Distamycins
- Nitrogen Mustard Compounds
- tallimustine
|
Topics |
- Aged
- Antineoplastic Agents
(administration & dosage, adverse effects, therapeutic use)
- Canada
- Carcinoma, Small Cell
(drug therapy, mortality, pathology)
- Disease Progression
- Distamycins
(administration & dosage, adverse effects, therapeutic use)
- Dose-Response Relationship, Drug
- Female
- Follow-Up Studies
- Humans
- Infusions, Intravenous
- Leukocyte Count
- Lung Neoplasms
(drug therapy, mortality, pathology)
- Male
- Middle Aged
- Neoplasm Recurrence, Local
- Neutropenia
(blood, chemically induced)
- Nitrogen Mustard Compounds
(administration & dosage, adverse effects, therapeutic use)
|