Atopic dermatitis successfully treated by eradication of Helicobacter pylori.

Abstract

A relationship between allergic diseases and Helicobacter pylori infection has recently been noted. We report a case of atopic dermatitis and H. pylori infection in a 14-year-old girl. She had had widespread diffuse skin erythema with erosions and pigmentation since the age of 3 years. Endoscopically, there was chronic antral gastritis with H. pylori infection and histological eosinophilic infiltration. A high titer of H. pylori-specific IgG was present in serum. She was treated with a proton pump inhibitor (lansoprazole 60 mg), an antibiotic (clarithromycin 800 mg), and plaunotol (a mucosal protective agent, 480 mg) for 2 weeks to eliminate the infection. After 10 days of treatment, erythema and itching were more widespread and vesicle formation was seen on the foot. Generalized skin lesions abated a few days later. After eradication of the bacterium by the treatment, eosinophils decreased from 38.8% to 19.0%, and the clinical signs of atopic dermatitis almost disappeared. Serum gastrin level and the pepsinogen I/II ratio were normalized and histological findings of gastric mucosa showed improvement. H. pylori-specific IgE antibody, analyzed by the Western blot method, gradually decreased with the eradication treatment.

• Authors: K Murakami, T Fujioka, A Nishizono, J Nagai, M Tokieda, R Kodama, T Kubota, M Nasu
• Journal: Journal of gastroenterology (J Gastroenterol) Vol. 31 Suppl 9 Pg. 77-82 (Nov 1996) ISSN: 0944-1174 [Print] Japan
• PMID: 8959527 (Publication Type: Case Reports, Journal Article)

Chemical References

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Anti-Bacterial Agents
• Anti-Ulcer Agents
• Diterpenes
• Fatty Alcohols
• Proton Pump Inhibitors
• Lansoprazole
• Clarithromycin
• Omeprazole
• plaunotol

Topics

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Adolescent
• Anti-Bacterial Agents (therapeutic use)
• Anti-Ulcer Agents (therapeutic use)
• Blotting, Western
• Clarithromycin (therapeutic use)
• Dermatitis, Atopic (drug therapy, microbiology)
• Diterpenes
• Drug Therapy, Combination
• Fatty Alcohols (therapeutic use)
• Female
• Gastric Mucosa (pathology)
• Gastritis (drug therapy, microbiology)
• Helicobacter Infections (diagnosis, drug therapy)
• Helicobacter pylori
• Humans
• Lansoprazole
• Omeprazole (analogs & derivatives, therapeutic use)
• Proton Pump Inhibitors