Sofalcone for treatment of Helicobacter pylori infection.

It is difficult to regard sofalcone as a single drug for the treatment of Helicobacter pylori infection. However, sofalcone exerts multiple effects against H. pylori: it has antibacterial activity, induces morphological changes, inhibits adhesion to gastric mucin and inhibits lipolytic activity. The safety profile of sofalcone even on long-term administration is well established. Therefore, it may be possible to establish a new triple therapy for H. pylori infection using sofalcone combined with antibacterial drugs and proton pump inhibitors.
AuthorsT Fujioka, K Murakami, T Kubota, R Kodama, S Honda, M Nasu
JournalJournal of gastroenterology (J Gastroenterol) Vol. 31 Suppl 9 Pg. 56-8 (Nov 1996) ISSN: 0944-1174 [Print] JAPAN
PMID8959521 (Publication Type: Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Anti-Ulcer Agents
  • Chalcones
  • sofalcone
  • Chalcone
  • Anti-Bacterial Agents (therapeutic use)
  • Anti-Ulcer Agents (therapeutic use)
  • Chalcone (analogs & derivatives, therapeutic use)
  • Chalcones
  • Drug Therapy, Combination
  • Helicobacter Infections (drug therapy)
  • Helicobacter pylori (drug effects)
  • Humans
  • Microbial Sensitivity Tests

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