HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Antimicrobial treatment of periodontal diseases disturbs the human ecology: a review.

Abstract
Periodontal diseases are associated with specific pathogenic microorganisms and therefore antimicrobial agents are often used in the treatment of patients with periodontitis refractory to conventional mechanical therapy. Perorally administered antimicrobial agents often lead to ecological disturbances in the normal oral and intestinal microflora with overgrowth of potentially pathogenic microorganisms, which may spread within the host or from patient to patient, causing infections. The use of antimicrobial agents also promotes the emergence of bacterial drug resistance, both in the periodontal pocket and in the normal oral and intestinal microflora. Topical administration of antimicrobial agents in the periodontal pockets causes restricted disturbances in the intestinal microflora, although there is a substantial risk of development of resistance at the site of application. A number of clinical studies imply that correct use of antimicrobial agents might be beneficial for a subset of patients with adult or juvenile periodontitis. The choice of antimicrobial agent should always be based on accurate microbial analyses of the subgingival microflora and in vitro antimicrobial susceptibility tests of the most important periodontal pathogens. Preferably, agents with low potential of causing ecological disturbances should be used.
AuthorsC Edlund, M Hedberg, C E Nord
JournalJournal of chemotherapy (Florence, Italy) (J Chemother) Vol. 8 Issue 5 Pg. 331-41 (Oct 1996) ISSN: 1120-009X [Print] England
PMID8957712 (Publication Type: Journal Article, Review)
Chemical References
  • Anti-Bacterial Agents
Topics
  • Anti-Bacterial Agents (adverse effects, therapeutic use)
  • Drug Resistance, Microbial
  • Ecosystem
  • Humans
  • Intestines (microbiology)
  • Mouth (microbiology)
  • Periodontal Diseases (drug therapy, microbiology)
  • Periodontitis (drug therapy, microbiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: