HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Cytogenetic and clinicobiological features of acute leukemia with stem cell phenotype: study of nine cases.

Abstract
Morphologic, immunologic, cytogenetic, and clinical features were studied in 9 cases of acute undifferentiated leukemia (AUL). These patients were unclassifiable by FAB criteria, they were CD34+ and did not express myeloid- or lymphoid-associated antigens (CD13, CD33, CD14, CD15, CD61, CD19, CD10, CD22, CD7, CD2, CD5, CD3). Clonal abnormalities were seen in 8 of 9 cases. Del(5q) as the sole anomaly was observed in 3 cases; +13 was the primary change in 3 cases, and isolated trisomy 12 was found in 1 patient. A complex karyotype with trisomy 12q, in association with del 17p and trisomy 21q was detected in 1 case. One patient with 5q- relapsed with refractory anemia with excess of blasts; the presence of dysgranulopoiesis and a few blasts with possible monocytoid morphology in the remaining 2 patients point to a "myeloid nature" of these leukemias. Analysis of cytologic features in our 3 patients with +13, in combination with previously reported cases, suggests the occurrence of immature stem cell involvement with limited differentiation potential, possibly more along the myeloid than the lymphoid lineage. The significance of trisomy 12q in this subset of leukemia remains elusive; some clues of minimal differentiation towards the myeloid lineage in our cases are provided by positivity for the CD117 (c-kit) antigen and by relapse with acute myeloid leukemia without maturation (M1) in one patient. We conclude that, with presently available diagnostic techniques, AUL is a rare subset of leukemia, in which cytogenetic changes are confined to a few chromosomes, with prevalent involvement of 5q and of chromosomes 13 and 12. Chromosome findings may be of value in clinical practice, especially in those cases with "myeloid-oriented" karyotype.
AuthorsA Cuneo, A Ferrant, J L Michaux, A Bosly, B Chatelain, M Stul, P Dal Cin, J Dierlamm, J J Cassiman, D K Hossfeld, G Castoldi, H Van den Berghe
JournalCancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 92 Issue 1 Pg. 31-6 (Nov 1996) ISSN: 0165-4608 [Print] United States
PMID8956868 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Acute Disease
  • Adolescent
  • Aged
  • Aged, 80 and over
  • Chromosome Aberrations
  • Humans
  • Immunophenotyping
  • Karyotyping
  • Leukemia (drug therapy, genetics, pathology)
  • Middle Aged
  • Remission Induction
  • Stem Cells

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: