| Abstract | Minocycline hydrochloride (MINO) at a dose of 500 mg (in principle) was injected into each of 11 hepatic cysts/10 cases (mean maximum diameter: 12.6 cm) that exhibited symptoms or a tendency toward growth by percutaneous transhepatic one puncture method, and the relation between therapeutic efficacy and pH of cystic fluid was examined. The efficacy was evaluated by abdominal CT after 3 months, and when a shrink of 50% or more in the maximum diameter was observed, it was judged as marked response. Marked effect was observed in 9 lesions of 11 (82%). This MINO injection therapy by one puncture method is very safe, simple and useful. Reduction in intra-cystic pH was not always related to the therapeutic efficacy, so involvement of cytotoxicity of MINO was suggested in degenerating the cystic epithelial cells. |
| Authors | Y Tanaka, M Ogino, H Tokuda, M Mizuno, M Yamauchi, Y Iijima, K Hattori, T Kato, Y Komatsubara, H Kato, K Hayashi
(Affiliation: Department of Gastroenterology, Nagoya Daini Red Cross Hospital.)
|
| Journal | Nippon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology
(Nippon Shokakibyo Gakkai Zasshi)
Vol. 93
Issue 11
Pg. 828-36
(Nov 1996)
ISSN: 0446-6586 JAPAN |
| PMID | 8953923
(Publication Type: Clinical Trial, English Abstract, Journal Article)
|
| Chemical References |
|
| Topics |
- Adult
- Aged
- Cysts
(drug therapy)
- Female
- Humans
- Injections, Intralesional
- Liver Diseases
(drug therapy)
- Male
- Middle Aged
- Minocycline
(administration & dosage)
- Treatment Outcome
|
