Abstract |
To compare the clinical and microbiological efficacy of azithromycin in curing chlamydial infections in women with that of lymecycline, and with a view of the possibility of minimizing the problem of compliance by means of single-dose administration, 146 women with culture-positive Chlamydia trachomatis infections were randomly assigned to treatment with a 1 g bolus dose of azithromycin or a 10-day course of lymecycline 300 mg twice daily. Clinical and microbiological evaluations were performed and adverse effects monitored at check-ups after 15-35 and 40-65 days. Of the 146 patients enrolled in the study, 120 were evaluable. At the second check-up, C. trachomatis was found to have been eradicated in all patients in both treatment groups. Of the 51 patients who had clinical signs and symptoms of genital infection at enrolment, 96% (22/23) of those in the azithromycin group were considered cured (n = 18) or improved (n = 4), as compared with 100% (28/28) of those considered cured (n = 22) or improved (n = 6) in the lymecycline group. Adverse events related, or possibly related, to treatment were reported by 16 (21.6%) of the lymecycline group, but by only 6 (8.3%) of the azithromycin group. The 2 drugs were comparable with regard to microbiological and clinical efficacy in the treatment of genital chlamydial infection in women. The markedly lower rate of side-effects associated with azithromycin may be a feature conducive to patient compliance.
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Authors | C Brihmer, P A Mårdh, I Kallings, S Osser, M Röbech, B Sikström, L Wanger |
Journal | Scandinavian journal of infectious diseases
(Scand J Infect Dis)
Vol. 28
Issue 5
Pg. 451-4
( 1996)
ISSN: 0036-5548 [Print] England |
PMID | 8953672
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Lymecycline
- Azithromycin
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Topics |
- Adult
- Anti-Bacterial Agents
(adverse effects, therapeutic use)
- Azithromycin
(adverse effects, therapeutic use)
- Chlamydia Infections
(drug therapy, microbiology)
- Chlamydia trachomatis
(isolation & purification)
- Double-Blind Method
- Female
- Genital Diseases, Female
(drug therapy, microbiology)
- Humans
- Lymecycline
(adverse effects, therapeutic use)
- Recurrence
- Safety
- Treatment Outcome
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