Effect of cabergoline, a long-acting dopamine D2 agonist, on reserpine-treated rodents.

Abstract

We studied the characterization of cabergoline, a new ergot alkaloid derivative and a selective dopamine D2 receptor agonist, in comparison to bromocriptine and pergolide in reserpine-treated rodents. Cabergoline (0.25-1.0 mg/kg, s.c.) improved dose-dependently the reserpine-induced akinesia that was assessed on the locomotor activity, and the efficacy lasted longer than those of bromocriptine (1.25-5.0 mg/kg, s.c.) or pergolide (0.0625-0.5 mg/kg s.c.). Cabergoline (ED50 = 1.10 mg/kg, at 4 h after the administration of drugs) also reversed catalepsy, the failure to correct an externally imposed posture, and its efficacy was stronger and longer than bromocriptine (ED50 = 4.65 mg/kg, at 4 h). Further, reserpine-induced rigidity was improved equally by cabergoline (0.125-1.0 mg/kg, i.v) and bromocriptine (1.0 mg/kg, i.v.). When cabergoline was administered together with 3(3,4-dihydroxyphenyl)-L-alanine (L-DOPA), the effects were additive. Our results indicate that the long-lasting effects of cabergoline could be beneficial for treating Parkinson's disease.

• Authors: M Miyagi, N Arai, F Taya, F Itoh, Y Komatsu, M Kojima, M Isaji
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 19 Issue 11 Pg. 1499-502 (Nov 1996) ISSN: 0918-6158 [Print] Japan
• PMID: 8951172 (Publication Type: Journal Article)

Chemical References

• Dopamine Agonists
• Ergolines
• Receptors, Dopamine D2
• Levodopa
• Reserpine
• Cabergoline

Topics

• Animals
• Cabergoline
• Dopamine Agonists (pharmacology)
• Ergolines (pharmacology, therapeutic use)
• Levodopa (pharmacology)
• Male
• Mice
• Motor Activity (drug effects)
• Parkinson Disease (drug therapy)
• Rats
• Rats, Sprague-Dawley
• Receptors, Dopamine D2 (agonists)
• Reserpine (pharmacology)