HLA associations in otosclerosis in Japanese patients.

Abstract

Otosclerosis is a disease of the otic capsule that is caused by abnormal resorption and redeposition of bony tissue. Sixty-two unrelated Japanese patients exhibiting clinical otosclerosis were typed for HLA-A, -B, -C antigens. Twenty-one of the patients were also typed for DR antigens. The frequency of HLA-Aw33 was significantly higher in otosclerosis patients than in the control group (24.2% vs 9.5%). This finding suggests that the presence of HLA-Aw33 antigens may be related to an increased susceptibility to otosclerosis or to its clinical outcome.

• Authors: T Miyazawa, C Tago, H Ueda, H Niwa, N Yanagita
• Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (Eur Arch Otorhinolaryngol) Vol. 253 Issue 8 Pg. 501-3 ( 1996) ISSN: 0937-4477 [Print] Germany
• PMID: 8950552 (Publication Type: Comparative Study, Journal Article)

Chemical References

• HLA Antigens

Topics

• Adolescent
• Adult
• Asian People
• Chi-Square Distribution
• Disease Susceptibility
• Female
• HLA Antigens (blood)
• Histocompatibility Testing
• Humans
• Japan
• Male
• Middle Aged
• Otosclerosis (ethnology, immunology)
• Phenotype
• Veins