Chromosome 18 translocation (18;21) (p11.1;p11.1) associated with psychosis in one family.

Abstract

In the course of recruiting families with 2 schizophrenic siblings for genome screening and linkage studies, a family was found with mental retardation, schizophrenia, and/or other related psychotic illnesses in individuals who also had an unbalanced or balanced translocation between chromosomes 21-18 [t(18;21)(p11.1;p11.1)]. The pericentric region of chromosome 18 has already been noted as a possible location of a gene for bipolar psychosis. The family described here provides further evidence that this region should be examined for a candidate psychosis gene.

• Authors: A B Smith, P Peterson, J Wieland, T Moriarty, L E DeLisi
• Journal: American journal of medical genetics (Am J Med Genet) Vol. 67 Issue 6 Pg. 560-3 (Nov 22 1996) ISSN: 0148-7299 [Print] United States
• PMID: 8950415 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Chromosome Banding
• Chromosomes, Human, Pair 18
• Chromosomes, Human, Pair 21
• Female
• Genetic Linkage
• Humans
• Intellectual Disability (genetics)
• Karyotyping
• Male
• Pedigree
• Psychotic Disorders (genetics)
• Schizophrenia (genetics)
• Translocation, Genetic