Neuroprotective effect of 4'-(4-methylphenyl)-2,2':6',2-terpyridine trihydrochloride, a novel inducer of nerve growth factor.

Abstract

We have identified 4'-(4-methylphenyl)-2,2':6',2-terpyridine: trihydrochloride (SS701), which belongs to a family of a small unique neuroprotective agents. SS701 accelerated the production of nerve growth factor (NGF) in cultured astroglial cells, dose- and time-dependently. In in vivo studies, SS701, when administered 30 min after induced cerebral ischemia, neuroprotective effects on delayed neuronal death in Mongolian gerbils were evident. The neuroprotective effects of SS701 against ischemia-induced delayed neuronal death are attributed to stimulation of the production of NGF.

• Authors: K Yamamoto, R Yoshikawa, S Okuyama, Y Takahashi, Y Karasawa, N Hino, T Miyoshi, H Araki, K Hanabusa, H Shirai, K Tomisawa
• Journal: Life sciences (Life Sci) Vol. 59 Issue 25-26 Pg. 2139-46 ( 1996) ISSN: 0024-3205 [Print] Netherlands
• PMID: 8950317 (Publication Type: Journal Article)

Chemical References

• Nerve Growth Factors
• Neuroprotective Agents
• 2,2'-Dipyridyl
• 4'-(4-methylphenyl)-2,2'-6',2''-terpyridine

Topics

• 2,2'-Dipyridyl (analogs & derivatives, pharmacology)
• Animals
• Arterial Occlusive Diseases (pathology)
• Astrocytes (drug effects, metabolism)
• Cell Death
• Cells, Cultured
• Female
• Gerbillinae
• Mice
• Mice, Inbred ICR
• Nerve Growth Factors (biosynthesis)
• Neurons (cytology, drug effects)
• Neuroprotective Agents (pharmacology)
• Pregnancy