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Tissue concentration of dimetridazole in laying hens.

Abstract
After laying hens had been dosed orally with dimetridazole (DMZ) for 3 days (50 and 250 mg/kg body weight (b.w.)) or intramuscularly, also for 3 days (50 mg/kg b.w.), the residues were determined in serum, liver, breast and thigh muscle by liquid chromatography. The limit of determination was 0.01 micrograms/g. The maximum concentration of DMZ was found at 1 h following application. After oral doses (50 and 250 mg/kg b.w.) no residues were found in muscle (breast and thigh) at 48 and 72 h, respectively. After intramuscular injection, residues in thigh muscle were below 0.01 micrograms/g at 72 h but breast muscle (injection site) still had concentrations above this level. Bioavailability (F > 80%) and some pharmacokinetic parameters were determined. The elimination half-lives from serum were 2.56h and 2.69h, after both oral doses, respectively, and 2.88 h after intramuscular application.
AuthorsA Posyniak, S Semeniuk, J Zmudzki, J Niedzielska, B Biernacki
JournalFood additives and contaminants (Food Addit Contam) 1996 Nov-Dec Vol. 13 Issue 8 Pg. 871-7 ISSN: 0265-203X [Print] England
PMID8950108 (Publication Type: Journal Article)
Chemical References
  • Antiprotozoal Agents
  • Dimetridazole
Topics
  • Administration, Oral
  • Animals
  • Antiprotozoal Agents (blood, pharmacokinetics)
  • Biological Availability
  • Chickens
  • Chromatography, Liquid
  • Dimetridazole (blood, pharmacokinetics)
  • Female
  • Half-Life
  • Injections, Intramuscular
  • Tissue Distribution

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