Abstract |
After laying hens had been dosed orally with dimetridazole (DMZ) for 3 days (50 and 250 mg/kg body weight (b.w.)) or intramuscularly, also for 3 days (50 mg/kg b.w.), the residues were determined in serum, liver, breast and thigh muscle by liquid chromatography. The limit of determination was 0.01 micrograms/g. The maximum concentration of DMZ was found at 1 h following application. After oral doses (50 and 250 mg/kg b.w.) no residues were found in muscle (breast and thigh) at 48 and 72 h, respectively. After intramuscular injection, residues in thigh muscle were below 0.01 micrograms/g at 72 h but breast muscle (injection site) still had concentrations above this level. Bioavailability (F > 80%) and some pharmacokinetic parameters were determined. The elimination half-lives from serum were 2.56h and 2.69h, after both oral doses, respectively, and 2.88 h after intramuscular application.
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Authors | A Posyniak, S Semeniuk, J Zmudzki, J Niedzielska, B Biernacki |
Journal | Food additives and contaminants
(Food Addit Contam)
1996 Nov-Dec
Vol. 13
Issue 8
Pg. 871-7
ISSN: 0265-203X [Print] England |
PMID | 8950108
(Publication Type: Journal Article)
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Chemical References |
- Antiprotozoal Agents
- Dimetridazole
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Topics |
- Administration, Oral
- Animals
- Antiprotozoal Agents
(blood, pharmacokinetics)
- Biological Availability
- Chickens
- Chromatography, Liquid
- Dimetridazole
(blood, pharmacokinetics)
- Female
- Half-Life
- Injections, Intramuscular
- Tissue Distribution
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