Inflammation of solar keratoses following systemic 5-fluorouracil.

Abstract

Several cutaneous reactions have been reported following systemic 5-fluorouracil (5-FU) for the treatment of malignancies. We report three patients with marked inflammation of the solar keratoses following continuous infusion of 5-FU for solid tumours. This side-effect with 5-FU, only previously reported in three other cases, was beneficial as most solar keratoses cleared following the inflammatory reaction. The reasons why 5-FU should be selectively taken up by solar keratoses are discussed.

• Authors: V Bataille, D Cunningham, J Mansi, P Mortimer
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 135 Issue 3 Pg. 478-80 (Sep 1996) ISSN: 0007-0963 [Print] England
• PMID: 8949450 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Fluorouracil

Topics

• Aged
• Antimetabolites, Antineoplastic (adverse effects)
• Erythema (chemically induced, pathology)
• Female
• Fluorouracil (adverse effects)
• Humans
• Keratosis (chemically induced, pathology)
• Male