Domoic acid: neurobehavioral and neurohistological effects of low-dose exposure in adult rats.
|
| Abstract |
Adult rats treated IP with domoic acid at 0, 0.22, 0.65, or 1.32 mg/kg were tested for passive avoidance (PA), auditory startle (AS), or conditioned avoidance (CAR) behaviors. Clinical signs were observed only at the 1.32 mg/kg dose level. Within 24 h of dosing, rats surviving a dose of 1.32 mg/kg exhibited transient decreased body weight and exaggerated AS responding. Startle latency and habituation, PA, and CAR were not affected. Examination of brains from six rats per group revealed a subset (2/6) of animals receiving 1.32 mg/kg domoic acid with degenerating neurons in the hippocampal CA1/CA3 subregions and gliosis. The decreased body weight and increased startle suggest a hyperreactivity syndrome possibly related to neuronal degeneration in the hippocampus. In a separate experiment, domoic acid at an IP dose of 0.93 mg/kg was found to produce hypomotility in addition to a decrease in body weight. Both effects were reduced by pretreatment with scopolamine (2 mg/kg), but not with caffeine (30 mg/kg), indicating a possible cholinergic involvement in domoate's toxicity.
|
|---|---|
| Authors | T J Sobotka, R Brown, D Y Quander, R Jackson, M Smith, S A Long, C N Barton, R L Rountree, S Hall, P Eilers, J N Johannessen, A C Scallet |
| Journal | Neurotoxicology and teratology (Neurotoxicol Teratol) 1996 Nov-Dec Vol. 18 Issue 6 Pg. 659-70 ISSN: 0892-0362 [Print] United States |
| PMID | 8947943 (Publication Type: Journal Article) |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!