Peribulbar anaesthesia for cataract surgery: prilocaine versus lignocaine and bupivacaine.

Abstract

PURPOSE:

Prilocaine has recently been introduced for use in ocular local anaesthesia. A prospective randomised double-masked study was undertaken to assess the efficacy of prilocaine 2% plain versus a mixture of lignocaine 1% and bupivacaine 0.5%, each with hyaluronidase.

METHODS:

Seventy-five patients were recruited. Local anaesthetic was given by a two-injection transconjunctival peribulbar technique. Injection and perioperative pain were graded by visual analogue pain score (range 0-10). Akinesia and orbicularis function were graded by the surgeon.

RESULTS:

The two anaesthetic mixtures were comparable in efficacy in producing anaesthesia and akinesia. Using the Mann-Whitney U-test for significance, pain of injection ranked as a mean of 0.88 for prilocaine and 1.03 for lignocaine and bupivacaine (p = 0.48, U = 635.5) Perioperative pain was ranked as a mean of 1.17 for prilocaine and 0.91 for lignocaine and bupivacaine (p = 0.41, U = 629.0).

CONCLUSIONS:

Prilocaine is a useful alternative anaesthetic agent for eye surgery that has low toxicity and is effective without adrenaline.

• Authors: T R Henderson, W Franks
• Journal: Eye (London, England) (Eye (Lond)) Vol. 10 ( Pt 4) Pg. 497-500 ( 1996) ISSN: 0950-222X [Print] England
• PMID: 8944106 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anesthetics, Local
• Prilocaine
• Lidocaine
• Bupivacaine

Topics

• Anesthetics, Local (therapeutic use)
• Bupivacaine (therapeutic use)
• Cataract Extraction
• Double-Blind Method
• Humans
• Lidocaine (therapeutic use)
• Pain Measurement
• Pain, Postoperative
• Prilocaine (therapeutic use)