Abstract | OBJECTIVE: To obtain clinically applicable data on the effects of regular human insulin and the LysB28,ProB29-human insulin analogue ( lispro) on the correction of incidental hyperglycemia. RESEARCH DESIGN AND METHODS: The insulins were compared in a non-clamped randomized crossover study of 27 male IDDM patients. Hyperglycemia was induced by the withdrawal of the normal evening dose of insulin; the next morning patients fasted and received a single dose of study insulin according to a dosing nomogram. Blood glucose concentration and GR (a measure of glucose corrected for differences in administered insulin dose: GR = glucose concentration X BMI X insulin dose-1) were followed for 4 h. RESULTS: CONCLUSIONS: The more rapid action of lispro is an advantage in the correction of hyperglycemia, even though actual differences in glucose concentrations are smaller than suggested by previous clamped studies.
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Authors | F Holleman, J J van den Brand, R A Hoven, J M van der Linden, I van der Tweel, J B Hoekstra, D W Erkelens |
Journal | Diabetes care
(Diabetes Care)
Vol. 19
Issue 12
Pg. 1426-9
(Dec 1996)
ISSN: 0149-5992 [Print] United States |
PMID | 8941477
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Hypoglycemic Agents
- Insulin
- Insulin Lispro
- Recombinant Proteins
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Topics |
- Adult
- Aged
- Blood Glucose
(metabolism)
- Cross-Over Studies
- Diabetes Mellitus, Type 1
(blood, drug therapy)
- Humans
- Hyperglycemia
(drug therapy)
- Hypoglycemic Agents
(therapeutic use)
- Insulin
(analogs & derivatives, therapeutic use)
- Insulin Lispro
- Male
- Middle Aged
- Multivariate Analysis
- Recombinant Proteins
(therapeutic use)
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