Abstract | OBJECTIVES: DESIGN: Multicenter, double-blind, double-dummy, randomized clinical trial. SETTING: Six academic departments specialized in the study of endometriosis. PATIENT(S): INTERVENTION(S): Six-month treatment with oral gestrinone (n = 27) or IM depot LA (n = 28) followed by 6-month follow-up. MAIN OUTCOME MEASURE(S): Variations in severity of dysmenorrhea, deep dyspareunia, and nonmenstrual pain as shown by a visual analog scale and a verbal rating scale, modifications in bone mineral content as shown by dual-roentgenogram absorptiometry, and variations in serum cholesterol subfractions and lipoprotein(a) concentrations. RESULT(S): Significant improvements were observed in all three symptoms considered in both treatment arms. Moderate or severe pain symptoms recurrence on both pain scales was observed in 2 of 17 (11.8%) patients given gestrinone compared with 9 of 17 (52.9%) of those given LA (odds ratio, 0.12; 95% confidence interval, 0.02 to 0.69). Lumbar bone mineral density increased slightly in the gestrinone group but decreased by 3% in the LA one. High-density-lipoprotein cholesterol fell by 25% and lipoprotein(a) decreased by approximately 40% in the gestrinone-treated women but did not vary in those receiving LA. CONCLUSION(S): Oral gestrinone is at least as effective as depot LA for pain relief in women with symptomatic endometriosis. A tendency to prolonged pain reduction was observed after gestrinone compared with LA treatment. Gestrinone does not negatively affect bone density but variations in serum lipids need further evaluation.
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Authors | |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 66
Issue 6
Pg. 911-9
(Dec 1996)
ISSN: 0015-0282 [Print] United States |
PMID | 8941054
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Lipids
- Progesterone Congeners
- Gestrinone
- Gonadotropin-Releasing Hormone
- Leuprolide
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Topics |
- Absorptiometry, Photon
- Adolescent
- Adult
- Bone Density
(drug effects)
- Double-Blind Method
- Dysmenorrhea
(drug therapy, physiopathology)
- Endometriosis
(complications)
- Female
- Gestrinone
(adverse effects, therapeutic use)
- Gonadotropin-Releasing Hormone
(agonists)
- Humans
- Leuprolide
(adverse effects, therapeutic use)
- Lipids
(blood)
- Pelvic Pain
(drug therapy, etiology, physiopathology)
- Progesterone Congeners
(adverse effects, therapeutic use)
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