Contact dermatitis caused by 2-HEMA and GM dentin primer solutions applied to guinea pigs and humans.

Abstract

The purposes of this study were to examine whether 2-HEMA, GM, and methacrylic acid cause contact dermatitis, and to determine the optimum concentrations of these primers for sensitization and challenge in guinea pigs. A sensitizing concentration of 0.2% 2-HEMA resulted in strong rubefaction and several vesiculopapules in response to the challenge, and a sensitizing concentration of 0.5% GM produced strong rubefaction at 24 hours. We also observed the development of contact dermatitis on human brachia in a closed-patch test. Skin that was treated with both 2-HEMA and GM clearly showed the onset of rubefaction and itchiness. 2-HEMA caused sensitized delayed allergic reactions at all the concentrations tested.

• Authors: K Katsuno, A Manabe, K Itoh, Y Nakamura, S Wakumoto, H Hisamitsu, T Yoshida
• Journal: Dental materials journal (Dent Mater J) Vol. 15 Issue 1 Pg. 22-30 (Jun 1996) ISSN: 0287-4547 [Print] Japan
• PMID: 8940535 (Publication Type: Journal Article)

Chemical References

• Dentin-Bonding Agents
• Glycerides
• Methacrylates
• methacrylic acid
• glyceryl methacrylate
• hydroxyethyl methacrylate

Topics

• Animals
• Dentin-Bonding Agents (adverse effects)
• Dentistry
• Dermatitis, Allergic Contact (etiology)
• Dermatitis, Occupational (etiology)
• Glycerides (adverse effects)
• Guinea Pigs
• Humans
• Male
• Methacrylates (adverse effects)
• Patch Tests