HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effect of ethambutol on emergence of clarithromycin-resistant Mycobacterium avium complex in the beige mouse model.

Abstract
An animal model was developed for studying macrolide-resistant Mycobacterium avium complex (MAC) and to measure the effect of ethambutol on resistance. MAC-infected beige mice were given clarithromycin daily; the frequency of clarithromycin-resistant MAC after 8 and 12 weeks was 10(-3) and 10(-2), respectively. Combined ethambutol plus clarithromycin did not increase anti-MAC activity, but clarithromycin-resistant MAC was less frequent (P < .05). The frequency of clarithromycin-resistant MAC in mice receiving the combination was significantly higher than that in untreated mice. These results are consistent with two human trials, which showed that adding ethambutol reduced the frequency of clarithromycin-resistant MAC. Results of the present study suggest that with an initially high level of MAC infection, the addition of ethambutol may only delay resistance. This mouse test system will be useful for investigating the influence of the level of MAC infection and the effect of other drugs on the frequency of resistant MAC.
AuthorsL E Bermudez, K A Nash, M Petrofsky, L S Young, C B Inderlied
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 174 Issue 6 Pg. 1218-22 (Dec 1996) ISSN: 0022-1899 [Print] United States
PMID8940212 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Anti-Bacterial Agents
  • Antitubercular Agents
  • RNA, Ribosomal, 23S
  • Ethambutol
  • Clarithromycin
Topics
  • Animals
  • Anti-Bacterial Agents (therapeutic use)
  • Antitubercular Agents (therapeutic use)
  • Clarithromycin (therapeutic use)
  • Disease Models, Animal
  • Drug Resistance, Microbial (genetics)
  • Drug Therapy, Combination
  • Ethambutol (therapeutic use)
  • Female
  • Genes, Bacterial (drug effects)
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Mutagenesis, Site-Directed
  • Mycobacterium avium Complex (drug effects, genetics, isolation & purification)
  • Mycobacterium avium-intracellulare Infection (drug therapy, genetics)
  • RNA, Ribosomal, 23S (genetics)
  • Spleen (microbiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: