The concentrations of the endogenous C19-steroids in hyperplastic prostatic tissue and the effect of finasteride treatment.

Abstract

The concentrations of the antiandrogenic endogenous steroid epitestosterone (epiT) and of testosterone, dihydrotestosterone (DHT) and androstenedione in the prostate were determined in tissue samples obtained from 21 patients who underwent suprapubic prostatectomy for benign prostatic hyperplasia. Fifteen patients received no hormonal treatment before surgery and the other 6 patients were pretreated for 8 weeks before surgery with an oral dose of 5 mg/day finasteride. The steroids were extracted and separated by high pressure liquid chromatography and determined by specific radioimmunoassays. The concentration of epiT (mean 58.4 +/- 40.4 S.D., range 14.0-144.0 fmol/mg protein) exceeded that of testosterone and was nearly as high as that of DHT. The prostatic tissue from the patients treated with finasteride for 8 weeks showed a significant decrease not only in DHT but also in androstenedione and epiT, whereas the concentration of testosterone increased significantly.

• Authors: M Hill, R Petrik, R Hampl, L Stárka
• Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme (Horm Metab Res) Vol. 28 Issue 10 Pg. 562-4 (Oct 1996) ISSN: 0018-5043 [Print] Germany
• PMID: 8934217 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 5-alpha Reductase Inhibitors
• Enzyme Inhibitors
• Steroids
• Dihydrotestosterone
• Testosterone
• Androstenedione
• Epitestosterone
• Finasteride

Topics

• 5-alpha Reductase Inhibitors
• Aged
• Androstenedione (metabolism)
• Dihydrotestosterone (metabolism)
• Enzyme Inhibitors (therapeutic use)
• Epitestosterone (blood)
• Finasteride (therapeutic use)
• Humans
• Male
• Middle Aged
• Prostatic Hyperplasia (drug therapy, enzymology, metabolism)
• Steroids (metabolism)
• Testosterone (metabolism)