The effect of chronic carbamazepine, valproic acid and phenytoin medication on the periodontal condition of epileptic children and adolescents.

Abstract

Periodontal condition was studied in 84 epileptic 8-18 year-old patients who had been undergoing antiepileptic drug (AEP) treatment for a period of at least 3 years. They were diagnosed as suffering from partial seizures (simplex or complex) or general tonic-clonic fits and were treated with therapeutic oral doses of phenytoin (PHT) and carbamazepine (CBZ) or valproic acid (VPA) in mono- or polytherapy. All patients received a drug dosage to ensure adequate plasma concentration and satisfactory seizure control. The Gingival Index (GI), Sulcus Bleeding Index (SBI) and Plaque Index (Pl-I) were individually scored. The control group contained 30 age-matched healthy children and adolescents. The GI and SBI indices were higher in epileptics than in controls. Only the Pl-I was similar in both groups. Gingival enlargement was found in 30% of the epileptic patients. There was no definite plasma concentration-dependent increase in the incidence of gingival overgrowth.

• Authors: B Galas-Zgorzalewicz, M Borysewicz-Lewicka, M Zgorzalewicz, E Borowicz-Andrzejewska
• Journal: Functional neurology (Funct Neurol) 1996 Jul-Aug Vol. 11 Issue 4 Pg. 187-93 ISSN: 0393-5264 [Print] Italy
• PMID: 8934150 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anticonvulsants
• Carbamazepine
• Valproic Acid
• Phenytoin

Topics

• Adolescent
• Anticonvulsants (adverse effects, blood, therapeutic use)
• Carbamazepine (adverse effects, blood, therapeutic use)
• Child
• Epilepsies, Partial (drug therapy)
• Epilepsy, Tonic-Clonic (drug therapy)
• Gingivitis (etiology, physiopathology)
• Humans
• Phenytoin (adverse effects, blood, therapeutic use)
• Valproic Acid (adverse effects, blood, therapeutic use)