Selective modulation of non-protein sulfhydryl levels in Ehrlich ascites tumor bearing mice.

Abstract

Thiazolidine derivatives (TD), prodrugs of L-cysteine (cys), synthesized by the condensation of cys with formaldehyde (thiazolidine-4-carboxylic acid-CF), acetaldehyde (2-methyl-thiazolidine-4-carboxylic acid-CA) and pyruvate (2-methylthiazolidine-2,4-dicarboxylic acid-CP), as well as amino acids thiocystine (T-cys) and cys, but not methionine (met) and S2O3(-2), successfully elevated non-protein sulfhydryl (NPSH) levels in livers of Ehrlich ascites tumor cells (EATC) bearing mice. At the same time, CA, promote a significant drop of NPSH concentration in EATC, whereas the other sulfur compounds (S-comp) have no effects. Thus TD and T-cys through their selective influence upon the level of NPSH in the liver and in cancer cells, seem to be the most interesting compounds for further studies on anticancer therapy.

• Authors: L B Włodek, M Wróbel
• Journal: Neoplasma (Neoplasma) Vol. 43 Issue 4 Pg. 259-63 ( 1996) ISSN: 0028-2685 [Print] Slovakia
• PMID: 8931751 (Publication Type: Journal Article)

Chemical References

• Amino Acids
• Prodrugs
• Thiazoles
• Thiosulfates
• thiocysteine
• Methionine
• Glutathione
• Cysteine

Topics

• Amino Acids (pharmacology)
• Animals
• Carcinoma, Ehrlich Tumor (metabolism)
• Cysteine (analogs & derivatives, pharmacology)
• Female
• Glutathione (metabolism)
• Liver (drug effects, metabolism)
• Methionine (pharmacology)
• Mice
• Neoplasm Transplantation
• Prodrugs (chemical synthesis, pharmacology)
• Thiazoles (chemical synthesis, pharmacology)
• Thiosulfates (pharmacology)