Abstract |
1S,3R-1-Aminocyclopentane-1,3-dicarboxylate (1S,3R-ACPD) and L-2-amino-4-phosphonobutyrate (L-AP4) are selective agonists of metabotropic glutamate receptors (mGluRs). 1S,3R-ACPD (200 nmol) injected into the amygdala (AM) of non-kindled rats produced immediate and transient seizures, characterized by immobility, searching, and wet-dog shakes. However, this ictal response was not observed in AM-kindled rats. Intra-AM injection of 1S,3R-ACPD (40 or 200 nmol) or L-AP4 (200 nmol) resulted in a delayed and marked suppression of kindled seizures, 3 days after 40 nmol of 1S,3R-ACPD, 1 day after 200 nmol of 1S,3R-ACPD, and from 1 to 3 days after 200 nmol of L-AP4. These and the previous findings suggest that: (1) the excitatory action of 1S,3R-ACPD in the AM, which may be mediated by the postsynaptic mGluRs, is reduced after completion of kindling; (2) 1S,3R-ACPD and L-AP4 exert anti- convulsant action in the AM, presumably by activating the presynaptic as well as postsynaptic mGluRs.
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Authors | K Suzuki, N Mori, H Kittaka, Y Iwata, Y Yamada, K Osonoe, S Niwa |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 204
Issue 1-2
Pg. 41-4
(Feb 02 1996)
ISSN: 0304-3940 [Print] Ireland |
PMID | 8929973
(Publication Type: Journal Article)
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Chemical References |
- Aminobutyrates
- Anticonvulsants
- Excitatory Amino Acid Agonists
- Receptors, Metabotropic Glutamate
- Cycloleucine
- 1-amino-1,3-dicarboxycyclopentane
- 2-amino-4-phosphonobutyric acid
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Topics |
- Aminobutyrates
(pharmacology)
- Amygdala
(drug effects, physiology)
- Animals
- Anticonvulsants
(pharmacology)
- Cycloleucine
(analogs & derivatives, pharmacology)
- Electroencephalography
(drug effects)
- Excitatory Amino Acid Agonists
(pharmacology)
- Injections
- Kindling, Neurologic
(drug effects)
- Male
- Rats
- Rats, Wistar
- Receptors, Metabotropic Glutamate
(agonists)
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