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Big insulin-like growth factor II-producing hepatocellular carcinoma associated with hypoglycemia.

Abstract
A 76-year-old female with a hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) was hospitalized because of fasting hypoglycemia. Her sera contained a low concentration of immunoreactive insulin and insulin-like growth factor (IGF)-I, while the IGF-II level was normal. However, most of the IGF-II consisted of the high molecular weight form (big IGF-II). The tumor tissue contained fetal type of IGF-II mRNA (6.0 kb). Furthermore, we found that one of the four patients examined with HCV-related HCC had big IGF-II in serum. This indicates that non-islet cell tumor hypoglycemia (NICTH) in HCV-related HCC might be accompanied by production of big IGF-II by the tumor.
AuthorsS Ishida, M Noda, N Kuzuya, F Kubo, S Yamada, T Yamanaka, O Isozaki, N Hizuka, Y Kanazawa
JournalInternal medicine (Tokyo, Japan) (Intern Med) Vol. 34 Issue 12 Pg. 1201-6 (Dec 1995) ISSN: 0918-2918 [Print] Japan
PMID8929651 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Insulin-Like Growth Factor II
Topics
  • Aged
  • Carcinoma, Hepatocellular (complications, diagnosis, metabolism)
  • Fatal Outcome
  • Female
  • Humans
  • Hypoglycemia (complications, diagnosis, metabolism)
  • Insulin-Like Growth Factor II (metabolism)
  • Liver Neoplasms (complications, diagnosis, metabolism)

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