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Tecogalan sodium inhibits corneal neovascularization induced by basic fibroblast growth factor.

Abstract
The antiangiogenic effect of tecogalan sodium on corneal neovascularization was investigated. Tecogalan sodium, a sulfated polysaccharide peptidoglycan complex isolated from an Arthrobacter species, has been reported to inhibit angiogenesis induced by basic fibroblast growth factor (bFGF) as well as tumor angiogenesis related to Kaposi's sarcoma. Corneal neovascularization induced by bFGF was inhibited by tecogalan sodium in a dose-dependent manner. Since bFGF is known to have a promoting effect on corneal neovascularization, tecogalan sodium may be possible therapeutic agent for corneal neovascularization, which can cause severe visual disturbances.
AuthorsT Murata, T Ishibashi, H Yoshikawa, A Khalil, H Inomata
JournalOphthalmic research (Ophthalmic Res) Vol. 27 Issue 6 Pg. 330-4 ( 1995) ISSN: 0030-3747 [Print] Switzerland
PMID8927305 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Polysaccharides, Bacterial
  • Fibroblast Growth Factor 2
  • tecogalan
Topics
  • Animals
  • Antineoplastic Agents (pharmacology)
  • Corneal Neovascularization (chemically induced, pathology, prevention & control)
  • Fibroblast Growth Factor 2
  • Polysaccharides, Bacterial (pharmacology)
  • Rabbits

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