Abstract |
The effect of an herbal prescription, S-113m, consisting of biota, ginseng and schizandra, on learning and memory performance was studied in the senescence accelerated mouse (SAM). A solid diet containing 1% (w/w) S-113m was given to SAM from 1 month of age. A behavioral experiment, started 4 or 9 months later, revealed prominent learning impairment in SAMP8, a senescence accelerated-prone mouse. Chronic ingestion of S-113m improved the memory retention disorder of SAMP8 in a passive avoidance test and increased the conditioned avoidance rate in a lever-press test at the age of 10 months. The preparation also facilitated the memory retention deficit in the passive avoidance test in 10-month-old SAMR1, a senescent resistant substrain. These results raise the possibility that S-113m might be useful for treating physiological aging and age-related memory deficits in human.
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Authors | N Nishiyama, P J Chu, H Saito |
Journal | Biological & pharmaceutical bulletin
(Biol Pharm Bull)
Vol. 19
Issue 3
Pg. 388-93
(Mar 1996)
ISSN: 0918-6158 [Print] Japan |
PMID | 8924907
(Publication Type: Journal Article)
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Chemical References |
- Drugs, Chinese Herbal
- S 113m
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Topics |
- Aging
(genetics, psychology)
- Animals
- Avoidance Learning
(drug effects)
- Drugs, Chinese Herbal
(pharmacology)
- Learning
(drug effects)
- Male
- Memory
(drug effects)
- Mice
- Mice, Inbred Strains
- Motor Activity
(drug effects)
- Panax
(chemistry)
- Plants, Medicinal
(chemistry)
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