Abstract |
Prolidase deficiency is a hereditary enzyme deficiency characterized dermatologically by chronic recurrent ulcers and scarring due to increased skin fragility. It has been speculated that the enzyme deficiency causes a relative deficiency of proline in the wounds of these patients and negatively affects clinical healing. Two ulcers in a 17-year-old girl with established prolidase deficiency were treated for 12 weeks with ointments containing amino acids in an open study comparing the effects of 5% proline and a combination of 5% proline plus 5% glycine. Both ointments caused significant reduction of the ulcer size (p < 0.02), but the 5% proline-5% glycine mixture caused a more rapid reduction (0.01 < p < 0.02). The results confirm previous findings in this rare inborn error of metabolism.
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Authors | G B Jemec, A T Moe |
Journal | Pediatric dermatology
(Pediatr Dermatol)
1996 Jan-Feb
Vol. 13
Issue 1
Pg. 58-60
ISSN: 0736-8046 [Print] United States |
PMID | 8919529
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Ointments
- Dipeptidases
- proline dipeptidase
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Topics |
- Administration, Topical
- Adolescent
- Chronic Disease
- Dipeptidases
(administration & dosage, deficiency, therapeutic use)
- Female
- Humans
- Ointments
(administration & dosage, therapeutic use)
- Skin Ulcer
(diagnosis, drug therapy, etiology)
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