Topical treatment of skin ulcers in prolidase deficiency.

Prolidase deficiency is a hereditary enzyme deficiency characterized dermatologically by chronic recurrent ulcers and scarring due to increased skin fragility. It has been speculated that the enzyme deficiency causes a relative deficiency of proline in the wounds of these patients and negatively affects clinical healing. Two ulcers in a 17-year-old girl with established prolidase deficiency were treated for 12 weeks with ointments containing amino acids in an open study comparing the effects of 5% proline and a combination of 5% proline plus 5% glycine. Both ointments caused significant reduction of the ulcer size (p < 0.02), but the 5% proline-5% glycine mixture caused a more rapid reduction (0.01 < p < 0.02). The results confirm previous findings in this rare inborn error of metabolism.
AuthorsG B Jemec, A T Moe
JournalPediatric dermatology (Pediatr Dermatol) 1996 Jan-Feb Vol. 13 Issue 1 Pg. 58-60 ISSN: 0736-8046 [Print] UNITED STATES
PMID8919529 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Ointments
  • Dipeptidases
  • proline dipeptidase
  • Administration, Topical
  • Adolescent
  • Chronic Disease
  • Dipeptidases (administration & dosage, deficiency, therapeutic use)
  • Female
  • Humans
  • Ointments (administration & dosage, therapeutic use)
  • Skin Ulcer (diagnosis, drug therapy, etiology)

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