Effects in vitro of pachymatismin, a glycoprotein from the marine sponge Pachymatisma johnstonii, on a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6).

Abstract

Pachymatismin is a new cytostatic factor extracted from the marine sponge Pachymatisma johnstonii Bowerbank 1842 (Demospongiae, Geodiidae), which has an antiproliferative effect in vitro on cells from a human non-small-cell bronchopulmonary carcinoma (NSCLC-N6). The substance, both administered as a continuous and discontinuous treatment, triggers the irreversible arrest of cells in the G0/G1 phase of the cell cycle and morphological changes, thereby causing their destruction. Taken all together, these observations suggest that pachymatismin would induce atypical terminal cellular differentiation.

• Authors: M Zidane, P Pondaven, C Roussakis, M T More
• Journal: Anticancer research (Anticancer Res) 1996 Sep-Oct Vol. 16 Issue 5A Pg. 2805-12 ISSN: 0250-7005 [Print] Greece
• PMID: 8917389 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Biological Factors
• Glycoproteins
• Intercellular Signaling Peptides and Proteins
• pachymatismin protein, Pachymatisma johnstonii

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Biological Factors (pharmacology)
• Carcinoma, Non-Small-Cell Lung (pathology)
• Cell Cycle (drug effects, genetics)
• Drug Screening Assays, Antitumor
• Glycoproteins (pharmacology)
• Humans
• Intercellular Signaling Peptides and Proteins
• Lung Neoplasms (pathology)
• Porifera (chemistry)
• Tumor Cells, Cultured (drug effects, pathology)