Abstract | OBJECTIVES: BACKGROUND: The humoral mechanisms regulating volume overload in CHF are not fully understood. Therefore, we investigated whether there is a role for CIF in this pathologic condition. METHODS: Plasma and urinary CIF levels were investigated in 23 patients with chronic CHF and compared with changes in plasma atrial natriuretic peptide ( ANP). Twelve patients without CHF served as control subjects. RESULTS: CHF was associated with a highly significant threefold increase in both plasma CIF levels (mean +/- SD 7.10 +/- 3.01 vs. 2.28 +/- 0.92 U/ml, p < 0.0001) and urinary CIF excretion (7,849 +/- 3,600 vs. 2,351 +/- 1,297 U/day, p < 0.0001) with respect to patients without CHF. CIF increased as a function of impairment in left ventricular ejection fraction (r = -0.703, p < 0.0001) and the severity of clinical status. Plasma ANP was also increased in patients with CHF, although to a lesser extent (68%, p = 0.0501) than plasma CIF, and was also significantly correlated with left ventricular ejection fraction (r = -0.552, p = 0.0004). CONCLUSIONS: Plasma and urinary CIF activities were strongly and very significantly increased in chronic CHF. In addition to ANP, this long-term natriuretic agent may be of potential importance in reducing fluid overload in CHF.
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Authors | J L Dubois-Randé, O Montagne, M Alvarez-Guerra, C Nazaret, B Crozatier, P Gueret, A Castaigne, R P Garay |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 28
Issue 6
Pg. 1464-70
(Nov 15 1996)
ISSN: 0735-1097 [Print] United States |
PMID | 8917259
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biological Factors
- Carrier Proteins
- Chlorides
- Sodium-Potassium-Chloride Symporters
- Atrial Natriuretic Factor
- Sodium
- Potassium
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Topics |
- Adult
- Aged
- Atrial Natriuretic Factor
(blood)
- Biological Factors
(blood, metabolism, urine)
- Carrier Proteins
(antagonists & inhibitors)
- Chlorides
(antagonists & inhibitors)
- Female
- Heart Failure
(blood, metabolism, urine)
- Humans
- Male
- Middle Aged
- Potassium
(antagonists & inhibitors)
- Sodium
(antagonists & inhibitors)
- Sodium-Potassium-Chloride Symporters
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