Automatic preparation of radiopharmacokinetic data for in vivo estimation of receptor biochemistry.

Abstract

UNLABELLED:

We present a fully automated region of interest (ROI) and motion correction program for the generation of heart and liver time-activity data resulting from a hepatic functional imaging study using [99mTc-]galactosyl-neoglycoalbumin (99mTc-NGA).

METHODS:

The program automatically draws heart and liver ROI and corrects for lateral movement of the subject. Eighty-four 99mTc-NGA studies, consisting of 32 healthy subjects and 52 patients with liver disease, were processed and submitted to an automated kinetic analysis that estimates the subject's asialoglycoprotein receptor concentration [R]o.

RESULTS:

When compared to time-activity data generated by operator-drawn ROIs without motion correction, the average reduced Chi-square of the kinetic analysis decreased significantly (p < 0.001) from 2.20 to 1.37 and the number of studies that satisfied quality control increased from 74 to 81 studies. Receiver operating characteristic of [R]o resulted in greater detectability (0.984 +/- 0.012 compared with 0.965 +/- 0.020) when automatic ROI generation was employed. Using the test criteria of 0.65 microM, the sensitivity of [R]o increased from 0.88 to 0.92 and the specificity increased from 0.96 to 0.97.

CONCLUSION:

Automated definition of liver and heart ROIs with motion correction, that reduces observational noise, increased the success rate of the radiopharmacokinetic analysis from 88% to 96%.

• Authors: J C Xu, D R Vera, R C Stadalnik
• Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 37 Issue 11 Pg. 1896-902 (Nov 1996) ISSN: 0161-5505 [Print] United States
• PMID: 8917199 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Albumins
• Asialoglycoprotein Receptor
• Asialoglycoproteins
• Organotechnetium Compounds
• Receptors, Cell Surface
• technetium Tc 99m neogalactoalbumin

Topics

• Albumins
• Asialoglycoprotein Receptor
• Asialoglycoproteins (metabolism)
• Heart (diagnostic imaging)
• Humans
• Image Processing, Computer-Assisted
• Liver (diagnostic imaging, metabolism)
• Liver Diseases (diagnostic imaging, metabolism)
• Movement
• Myocardium (metabolism)
• Organotechnetium Compounds
• ROC Curve
• Radionuclide Imaging
• Receptors, Cell Surface (metabolism)